Research
Title : | Synthesis of C-aryl Septanosides as Analogues of C-aryl Glycosidic Inhibitors |
Area of research : | Chemical Sciences |
Principal Investigator : | Dr. Bhagavathy Shanmugasundaram, B.S.Abdur Rahman Crescent Institute Of Science & Technology, Tamil Nadu |
Timeline Start Year : | 2022 |
Timeline End Year : | 2025 |
Contact info : | bhagavathy@crescent.education |
Equipments : | HPLC accessories Rotary Evaporator Water chiller (-30 deg C) High vacuum pump |
Details
Executive Summary : | Many naturally occurring C-aryl glycosides are known to possess antibiotic and anticancer characteristics. Few of C-aryl glycosides have also been identified as a versatile class of SGLT2 type inhibitors such as dapagliflozin. There is still search for a more active carbohydrate-based glycans as glycosidase inhibitors. Moving from a six membered to a seven membered ring analogues of C-aryl hexopyranosides i.e. C-aryl septanosides is expected to show enhanced pharmacological activity. These C-aryl septanosides are hitherto unknown in literature. About four new strategies have proposed here towards the synthesis of C-aryl septanosides. If successfully prepared, these C-aryl septanosides will be tested for its anticancer and antidiabetic activity. |
Total Budget (INR): | 23,26,500 |
Organizations involved
Implementing Agency : | B.S.Abdur Rahman Crescent Institute Of Science & Technology, Tamil Nadu Funding Agency :Anusandhan National Rsearch Foundation (ANRF)/Science and Engineering Research Board (SERB) | Source:Science and Engineering Research Board (SERB), DST 2022-23 | |