Research

Engineering Sciences

Title :

Non-invasive 3D vector modeling of depolarization sequences using Magnetocardiography in Cardiomyopathy study

Area of research :

Engineering Sciences

Principal Investigator :

Dr. Vikas R Bhat, Manipal Institute Of Technology-Manipal Academy Of Higher Education, Karnataka

Timeline Start Year :

2022

Timeline End Year :

2025

Contact info :

Details

Executive Summary :

Bioelectromagnetism is a multidisciplinary domain that studies the electromagnetic phenomena evolved from the excitable biological tissues of the human body. Examples of such excitable tissues are present in the neuron cells of the brain, cardiac cells, and other skeletal muscle cells. The researchers of the biomedical society have been investing time for tracing and studying the electrophysiology of these cells by modeling them. The electrophysiology of these cells is detected across the body by using electrodes and the study is called Electrocardiography. Clinicians use ECG as a primary diagnostic tool to administer the functionality of heart diseases. Since this tool provides information at the surface level, sometimes clinicians may need further structural markings to confirm or localize the diseases with the help of non-invasive procedures. In the biomedical society, researchers have contributed many works to minimize the invasive procedures in the diagnosis of heart diseases. Since the cardiac current flow is responsible for generating a tiny magnetic field across the human thorax, researchers developed non-contact and non-invasive equipment called Magnetocardiogram (MCG) to record bio-magnetic fields. The direction of this research is to non-invasively image the myocardial activities. In certain heart disease cases, the clinicians might have to confirm the diagnosis by performing imaging or surgical procedures. Some clinical invasive assessments may either take much time or lead to further complications (sometimes) if the subject is prone to other diseases. Therefore, there is a need to trace out or visualize the heart activities in a non-invasive way by using modern methods. The researchers came up with the idea of deriving the computer-based generic or subject-specific heart-torso models that helped the medical professional to visualize and administer the diseases in a simple manner. The results of this research promise the clinicians an advantage of diagnosing/localizing the cardiomyopathy region or any other cardiac-related diseases at the cellular levels of the myocardium. The study provides the advantage of source localization with high accuracy. This serves as an inspiration to design an online system for non-invasive monitoring of inverse solutions during MCG recording where the clinician will be able to view the unknown functional activities on the screen.

Total Budget (INR):

15,99,400

Organizations involved