Medical Sciences

Title :

Non-alcoholic fatty liver disease (NAFLD): Novel pathogenic mechanism and therapeutic development

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Non-alcoholic fatty liver disease

Principal Investigator :

Dr Partha Chakrabarti, Scientist, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: Role of Ubiquitin-proteasome system (UPS) in the pathogenesis of NAFLD; Role of non-coding RNA in NAFLD; ER stress - Mitochondrial dysfunction - Autophagy triad during progression of NAFLD and to NASH; Targeted small molecule inhibitors for treatment of NAFLD by preventing ATGL degradation; Development of Novel mTOR inhibitors for reduction of lipogenesis and lipid accumulation in Hepatocytes; Identification of potential leads from Indian traditional medicinal plants against NAFLD.

Organizations involved