Life Sciences & Biotechnology
Title : | Construction of Universal Single Pot Human antibody libraries from Indian donors |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. Rajesh Kumar, Indian Institute Of Technology (IIT) Roorkee, Uttarakhand |
Timeline Start Year : | 2022 |
Timeline End Year : | 2024 |
Contact info : | rajesh.kumar@bt.iitr.ac.in |
Equipments : | Bacterial Shaker
Bacterial Shaker |
Details
Executive Summary : | The pace of discovery of novel antibody therapies is continually increasing as new antibody discovery tools are developed. This can be due to MAbs' numerous benefits over small molecule medicines, such as their longer circulation half-life, high target selectivity, and capacity to activate the immune system, allowing them to treat medical diseases for which there were no effective therapies until recently. MAbs with significant protective capacity against a wide variety of related infections or strains (broadly neutralizing antibodies [bNAbs]) are of great interest for antibody discovery and have promising immunotherapeutic applications. Great strides have been made in the past three to four decades, in the fields of cancer therapy, autoimmune disorders, cardiovascular disease, and infectious diseases. The majority of antibodies under development are targeted against chronic illnesses such as cancer, autoimmune and inflammatory disorders, which have large profit margins in the US and European markets. However, there are few antibodies in the clinical pipeline for treating infectious illnesses, and even fewer antibodies for treating infectious pathogens that mostly impact low and middle-income nations. The vision of this proposal is to discover and develop recombinant monoclonal antibodies that will directly treat illnesses with significant global health burdens in LMIC countries through the establishment and strengthening of the “Universal recombinant antibody library system” in India. Herein, we propose to develop universal antibody libraries that can be directly used for isolation of mAbs by laboratories in India working on different aspects of diseases. The main goal of this proposed platform is to develop a rapid system for isolation of human mAbs in a time frame of 4 to 6 weeks irrespective of the disease target. |
Total Budget (INR): | 31,02,840 |
Organizations involved