Life Sciences & Biotechnology
Title : | Co-ordination between stem cell activation, cell division and trans-differentiation guiding the reunion of disconnected tissues: Dissecting the fundamental principles of a phenomenon previously unknown in plant. |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Plant Biology, Cellular and Molecular Biology |
Principal Investigator : | Dr. Kalika Prasad , Indian Institute of Science Education and Research (IISER) Pune, Maharashtra |
Timeline Start Year : | 2022 |
Timeline End Year : | 2025 |
Contact info : | kalikasaksham11@gmail.com |
Equipments : | - 20 degree deep freezer
Laboratory Refrigerator
Binocular Stereo Zoom Microscope
Nano drop Spectrophotometer
Plant Growth chamber |
Details
Executive Summary : | Vascular regeneration studies in plants were pioneered by Jacobs and Sachs as early as1952, but the area remained less investigated thereafter, especially with respect to growing lateral organs such as leaves.For decades, it was believed that leaves growing in a normal developmental context cannot repair the local injuries caused by biotic and abiotic factors, until our recent finding proved other-wise(Radhakrishnan et al., 2020).It is the first study ever to demonstrate the leaf’s regenerative ability and to discover the mechanism underlying polarized growth of regenerating vein in growing leaves.Although veins are of utmost physiological relevance for plant’s survival, the cellular and molecular basis of the recognition and communication between the physically disconnected vascular strands which enables its reunion, hitherto remains unknown.While probing the regulation of fundamental cellular behavior during vein regeneration, we intent to fathom the coordination between stem cell activation, cell division and trans-differentiation, and how it guides the reunion of disconnected vein.The proposed study aims to dissect the fundamental principles of this coordinated interaction, a phenomenon previously unknown in plants.The premise of the proposal is to establish a link between stress signaling, cell division, stem cell activation and trans-differentiation, and to provide a deeper insight into how their coordinated interaction guides the regeneration of highly polarized vein. |
Co-PI: | Dr. Anjan Kumar Banerjee, Indian Institute of Science Education and Research (IISER) Pune, Maharashtra-411008 |
Total Budget (INR): | 86,90,586 |
Organizations involved