Life Sciences & Biotechnology

Title :

 Unraveling the neuroprotective mechanism of Vitexin and Thymol synergistic combination against tau hyperphosphorylation and neuroinflammation: a therapeutic approach for the treatment of Alzheimer’s disease

Area of research :

Life Sciences & Biotechnology

Focus area :

Biotechnology, Neurology

Principal Investigator :

Dr. Pandima Devi Kasi, Professor, ALAGAPPA UNIVERSITY, Karaikudi

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Alzheimer's disease is a multifactorial disease causing neurodegeneration. FDA-approved drugs, such as amyloid, cholinesterase, and NMDAR inhibitors, provide symptomatic relief but have side effects. Botanical preparations, like flavonoids, alkaloids, and terpenoids, have less side effects and potency in attenuating neurodegeneration. Targeting inflammation in brain cells is crucial for AD management. A proposed study will screen the synergistic combination of these compounds for their protective properties against tau phosphorylation and inflammation.

Total Budget (INR):


Organizations involved