Executive Summary : | The proposed research focuses on the synthesis and characterization of new nano bioactive glass-ceramics and bioresorbable glass particles made using the sol-gel technique via the Stober method. The main aim is to select the sol-gel synthesis that will be used for the modified Stober method, which is one of the most convenient routines for producing monodispersed phosphate nanoparticles spheres in the nano size range (from 50 to 80 nm), including nBGCs. The final composition will be controlled after syntheses, and the best derived results will be chosen for further studies and modifications. Various metallic ions such as Ce3+, Ga3+, Cu2+, Ag+, and Zn2+ have been added to the composition to improve its biological performance. Ionic dissolution products of nBGCs have been shown to induce osteogenic differentiation of stem cells and enhance osteoblast proliferation in vitro antibacterial activities. Various characterization techniques will be employed to probe the structural properties of these nBGCs. In-vitro bioactivity will be analyzed by immersing the samples in a Simulated Body Fluid solution, and the degradation kinetics of the glass ceramics will be assessed from weight loss and pH measurements. The detailed biological behavior of the prepared bioglass-ceramics will be explored through in vitro measurements of cytocompatibility, cell viability, cell proliferation, and antibacterial to understand their biocompatibility with tissues. Bioactive glass and ceramics are also suitable as nBGCs materials for implants to improve bone growth behavior. |