Research
Title : | Deciphering the redox chemistry of physical plasma-treated clinically-relevant liquids as novel therapy against ovarian cancer |
Area of Research : | Pharmaceutical Sciences |
Focus Area : | Pharmacology, Toxicology |
Principal Investigator : | Dr. Naresh Kumar, Ramalingaswami fellow, National Institute of Pharmaceutical Education and Research (NIPER-G), Guwahati |
Co-PI: | Dr. BidyaDhar Sahu, National Institute of Pharmaceutical Education and Research (NIPER-G), Guwahati |
Timeline Start Year : | 2021 |
Total Budget (INR): | 51,14,669 |
Details
Executive Summary : | This project aims to identify the optimal tumor-toxic target chemistry of plasma-treated liquids (PTL) as anticancer agents. The project will use clinically-relevant liquids and experimental methods to optimize plasma redox chemistry. The PTLs will be tested in vitro for efficacy in treating metastatic ovarian cancer, a common cancer in young women. The molecular basis of anticancer PTL redox effects will be investigated, and the best plasma condition will be investigated for pre-clinical impact. The novel redox-active PTL approach will be tested in mice. |