Medical Sciences

Title :

In vivo RNAi mediated intervention in neuro-inflammation pathway for development of therapeutic strategy

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Neuro-inflammation pathway

Principal Investigator :

Beena Pillai, Scientist, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: To study the effect of (1a) miR-29 mimic (1b) miRNA against anti-interferon gamma mRNA and (1c) anti-VDAC1 peptide (developed by international collaborator) in reducing the expression of interferon gamma induced genes in cell lines and in vivo mouse brain. To generate an (2a)AAV9-TBP system (2b) AAV9-HTT system with embedded intrans containing shRNA against the endogenous gene. Evaluate the efficacy of agents developed in (1) and (2) on HTT mice to revert neurodegeneration and ataxia.

Organizations involved