Research
Title : | In vivo RNAi mediated intervention in neuro-inflammation pathway for development of therapeutic strategy |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Neuro-inflammation pathway |
Principal Investigator : | Beena Pillai, Scientist, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | beena@igib.res.in |
Details
Executive Summary : | Objective: To study the effect of (1a) miR-29 mimic (1b) miRNA against anti-interferon gamma mRNA and (1c) anti-VDAC1 peptide (developed by international collaborator) in reducing the expression of interferon gamma induced genes in cell lines and in vivo mouse brain. To generate an (2a)AAV9-TBP system (2b) AAV9-HTT system with embedded intrans containing shRNA against the endogenous gene. Evaluate the efficacy of agents developed in (1) and (2) on HTT mice to revert neurodegeneration and ataxia. |
Organizations involved
Implementing Agency : | CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi Funding Agency :Council of Scientific and Industrial Research (CSIR), Government of India | Source (more info) :https://csirprojects.anusandhan.net/ | |