Medical Sciences

Title :

Study on the effect of a novel quorum sensing inhibitor isolated from Streptomyces sp. as an adjunct therapy molecule against latent and persisters in Mycobacterium tuberculosis

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Molecular medicine for Tuberculosis

Principal Investigator :

Dr Vijay Chintaman Sonawane, Scientist, CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: Production, isolation and purification of the QSI molecule, unravelling its structure. iStudy on the effect of the QSI in lowering of MIC of antitubercular drugs by co-administration of QSI. Study on Inhibition of biofilm formation by M. tuberculosis/M. smegmatis in the presence of QSI (in vitro) . (RNS) tolerance in M. tuberculosis. Study on effect of QSI on DOS regulon in M. tuberculosis which is involved in latency.

Organizations involved