Executive Summary : | Sensitivity analysis is a crucial technique for understanding the augmentation of drug concentration in clinical scenarios. Magnetic targeting nanoparticle drug delivery enhances drug concentration in affected regions and reduces adverse side effects. This method is beneficial in treating gene therapy, hepatic, hyperthermia, renal, pancreatic, cancers, and prostate. The ability to provide multiple doses is crucial. To accurately predict blood flow behavior, it is essential to consider blood viscosity variation. Few researchers have addressed magnetic targeted drug delivery in arteries with stenosis with radiative heat and mass transfer. The governing equations for flow field will be solved using Adomian Decomposition Method and finite volume method (FVM) based on SIMPLE with staggered grids. Results will be compared with ANSYS/COMSOL simulation results to validate implementation. The project aims to identify and elaborate on the nature of magnetically targeted drug delivery in circular arteries, the significance of hybrid nanoparticles, the effect of nanoparticle shape in circular blood vessels in the presence of stenosis with variable nanofluid viscosity, and the dominance of physical parameters through sensitivity analysis. The project will also build a patient-specific analysis framework for available technologies to analyze clinical trial data for insights into peripheral arterial disease management. |