Life Sciences & Biotechnology
Title : | Resolution of Bitot's spots after administration of mega-dose of vitamin A in a cohort of children in 1-5 years of age with Bitot's spot |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Nutrition |
Principal Investigator : | Umesh Kapil, All India Institute of Medical Sciences (AIIMS), New Delhi 110029 |
Timeline Start Year : | 2010 |
Timeline End Year : | 2012 |
Contact info : | umeshkapil@gmail.com;
shraddha.dwivedi@gmail.com;
hpssachdev@gmail.com;
dwivedi@hotmail.com;
rmpandey@yahoo.com |
Details
Executive Summary : | Bitot’s spot is a useful indicator of vitamin A deficiency, especially in young children, but is not pathognomonic. Substantial non-response to MVAS at 6 and 12 months of follow-up suggests that presently in the Indian subcontinent, Bitot’s spot is a relatively crude indicator of severe current vitamin A deficiency. Thus for programmatic decisions and evaluation, public health burden of VAD should not be solely assessed through BS; it would be desirable to consider other important health consequences. The findings may also partially explain: (i) the recorded discrepancy between BS and low serum retinol prevalences at population level in India; and (ii) the fact that the predominant decline in BS prevalence, antedated a functioning universal vitamin A supplementation programme in India . This decline has, however, now stagnated for a considerable period despite an improvement in MVAS coverage suggesting that factors other than severe VAD deficiency may be operating. It would be useful to revisit the guidelines for management of individual children with BS. |
Co-PI: | Prof. Umesh Kapil, Professor, All tndia Institute of Medical Sciences Ansari Nagar, New Delhi-110029, Prof. Shraddha Dwivedi
Professor and Head,
Department of Community Medicine MLN Medical College, Allahabad Uttar Pradesh shraddha.dwivedi@gmail.com
Prof. H.P.S. Sachdev
Senior Consultant Pediatrics and Clinical Epidemiology Sitaram Bhartia Institute of Science and Research B-16, Qutab Institutional Area, New Delhi-110016
hpssachdev@gmail.com
Prof. S.N. Dwivedi
Professor, Department of Biostatistics All tndia Institute of Medical Sciences Ansari Nagar, New Delhi-110029 dwivedi7 @hotmail.com
Dr. R.M. Pandey
Professor and Head
Department of Biostatistics
All India Institute of Medical Sciences Ansari Nagar, New Delhi-110029
rmpandey@yahoo.com |
Achievements : | Trained 01 SRF and 04 field investigators |
Publications : | 1 |
Outcome/Output: | Substantial non-response to MVAS at six months (49%) and one year (40%) of follow-up suggests that presently in the Indian subcontinent, Bitot’s spot is a relatively crude indicator of severe current vitamin A. |
Organizations involved
