Computer Sciences and Information Technology

Title :

Proteo-genomic analysis of SARS-CoV-2: A clinical landscape of SNPs, COVID-19 proteome and host responses

Area of research :

Life Sciences & Biotechnology, Computer Sciences and Information Technology, COVID-19 Research

Focus area :

Analysis of COVID-19

Principal Investigator :

Prof Utpal Tatu, Indian Institute of Science (IISc), Bengaluru

Timeline Start Year :


Contact info :


Executive Summary :

A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 and continues to be a global health challenge. Proteo genomic analysis using next generation sequencing (NGS) and mass spectrometry on nasopharyngeal swabs of COVID-19 patients to examine clinical genome and proteome is carried out. The study confirms the mutability of SARS-CoV-2 showing multiple SNPs. Host proteome analysis revealed several key host proteins to be uniquely expressed in COVID-19 patients. Pathway analysis of these proteins points towards modulation in immune response, especially involving neutrophil and IL-12 mediated signaling. Besides revealing the aspects of host-virus pathogenesis, the study opens new avenues to develop better diagnostic markers and therapeutic approaches.

Organizations involved