Executive Summary : | Mechanochemistry is gaining popularity in synthetic chemistry, materials chemistry, and pharmaceutical chemistry due to its potential to avoid toxic solvents and provide innovative synthetic methodologies. Traditional solution-based methods have been dominant in modern synthetic chemistry, but they have disadvantages such as using toxic solvents and causing environmental issues. Synthesis of organic compounds or ligands involves toxic solvents, high temperatures, low yield, and hectic reaction workup. In supramolecular chemistry, the synthesis of macrocycles is an integral part, but cyclization is a key step, often leading to polymeric products rather than cyclic ones. This research proposal aims to develop a new efficient synthetic methodology in the smell of mechanochemistry, which is considered one of the best methods of green chemistry. The absence of bulk solvent can create new synthetic methodologies that improve selectivity, enhance reaction rate, improve yield, and eliminate long reaction work-up. Techniques like liquid-assisted grinding (LAG) and mechanical grinding can be used to achieve this. The research will focus on organic and inorganic reactions under mechanical conditions and characterize the product with various spectroscopic methods. The goal is to find suitable reaction kinetic models to elucidate the reaction mechanism. The research proposal aims to help design a suitable synthetic methodology that is an enigma in solution-based chemistry. |