Cognitive Sciences and Psychology
Title : | Isolation, characterization and pharmacological evaluation of seaweed poly-/oligosaccharides in inorganic arsenic exposure-induced cognitive impairments by targeting gut-microflora-brain axis |
Area of research : | Cognitive Sciences and Psychology |
Focus area : | Neurotoxicology, Biological Science |
Principal Investigator : | Dr. Dhirendra Pratap Singh, Scientist C, ICMR- National Institute of Occupational Health |
Timeline Start Year : | 2023 |
Details
Executive Summary : | Arsenic, a common environmental toxins, has been linked to neurotoxic effects on the gut microbiota. Seaweed polysaccharides, which are FDA-approved food ingredients, have potential for use in cognition management. Researchers aim to extract and chemically characterize these polysaccharides from seaweeds and prepare their oligomers. The extracts will be evaluated in a validated rodent model against inorganic arsenic exposure-induced cognitive impairments. The study also aims to identify new therapeutic options for treating SYNGAP1-related Intellectual Disability (ID) and Autism Spectrum Disorder (ASD) in children. A small molecule activator, TTK21, has been found to induce long-term memory and assist in the complete recovery of memory in Alzheimer's mice. |
Co-PI: | Dr. Kamalesh Prasad, CSIR-Central Salt Marine Chemicals Research Institute, Gujarat;, Dr. Pramod Bapurao Shinde, CSIR-Central Salt Marine Chemicals Research Institute , Gujarat;, Dr. Santasabuj Das, National Institute of Cholera and Enteric Diseases, West Bengal;, Dr. Ramavatar Meena, CSIR-Central Salt Marine Chemicals Research Institute, Gujarat |
Total Budget (INR): | 39,36,360 |
Organizations involved