Life Sciences & Biotechnology
Title : | To investigate the catalytic and non-catalytic roles of replicative DNA polymerases in preserving replication fork integrity during replication stress |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Genetics |
Principal Investigator : | Dr Rais Ahmad Ganai, Assistant Professor, Islamic University of Science & Technology (IUST), Jammu & Kashmir |
Timeline Start Year : | 2021 |
Contact info : | rais.ganai@islamicuniversity.edu.in |
Associated Programme / Scheme : | Core Research Grant (CRG) |
Details
Executive Summary : | The study intends to understand the role of the leading strand Polymerase, Pol epsilon in maintaining the replication fork integrity separate from its role in the synthesis of the leading strand. Pol2, the catalytic subunit of DNA Pol epsilon is the focus of this project. Investigators will identify proteins that assist Pol epsilon during normal and stressful settings to preserve the integrity of the genome. This work will help elucidate the mechanistic pathways by which Pol epsilon, other associated factors and checkpoint machinery act & interact to fine-tune the stability of the replication fork stability. |
Co-PI: | Dr Mushtaq Ahmad Siddiqi, Assistant Professor, Islamic University of Science & Technology (IUST), Jammu & Kashmir |
Total Budget (INR): | 52,86,000 |
Organizations involved
