Life Sciences & Biotechnology
Title : | Hyperglycaemia in pregnancy
and risk of chronic diseases (MAASTHI) |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Diabetes |
Principal Investigator : | Dr Giridhara R Babu, Professor, The Public Health Foundation of India (PHFI), New Delhi |
Timeline Start Year : | 2015 |
Timeline End Year : | 2020 |
Contact info : | giridhar@iiphh.org |
Details
Executive Summary : | Maternal Antecedents of
Adiposity and Studying the Transgenerational role of Hyperglycemia and Insulin (MAASTHI) is a cohort study in the public health facilities in Bangalore, India. The objective of MAASTHI is to prospectively assess the effects of glucose levels in pregnancy on the risk of adverse infant outcomes, especially in predicting the possible risk markers of later chronic diseases. The primary objective of the proposed study is to investigate the effect of glucose levels in pregnancy on skinfold thickness (adiposity) in infancy as a marker of future obesity and diabetes in offspring. The secondary objective is to assess the association between psychosocial environment of mothers and adverse neonatal outcomes including adiposity. Pregnant women with a gestational period of less than 36 weeks will be recruited. A baseline questionnaire is administered that includes socio-economic status, Standard of Living Index, 24-hour dietary recall, dietary habits, physical activity, obstetrics history, psychosocial stressors and social support. Weight, height, sitting height, skinfold thickness of biceps, triceps and subscapular skinfold will be recorded. Blood pressure is measured using an automated BP apparatus. All women underwent an Oral Glucose Tolerance Test (OGTT) at 24 to 36 weeks of gestation. They were asked to fast for a minimum 8 h prior to the study visit, where fasting samples was drawn. Subsequently, 75 g of glucose was given and the postprandial sample was drawn after two hours. |
Total Budget (INR): | 3,90,90,363 |
Achievements : | 1. The study has recruited 4717 pregnant women and 2973 have underwent OGTT. Follow ups completed at birth, 1 year, 2nd year, 3rd year are 2054, 913, 546 and 77respectively.
2. The blood samples of 2900 pregnant women are stored in -80 freezer for future biochemical and genetic analysis.
3. After the initiation of Oral glucose tolerance test at the public hospital, the hospital administration has started diabetes clinic where pregnant women who are screened positive for GDM are offered consultation by General Physician. |
Publications : | 5 |
PhD Produced : | 4 ongoing |
Innovation (Innovations/ Patents/ Tech Transfer) : | We found that high mental
distress was related to small for gestational age babies. Also, the findings from this study may help to address important questions on screening and management of high blood sugar in pregnancy. It may provide critical information on the specific determinants driving the underweight-obesity-T2DM epidemic in India. |
Outcome/Output: | The study can inform the
policy regarding the potential impact of screening and management protocols in public healthcare facilities. The public health implications include prioritising issues of maternal glycemic control and weight management and better understanding of the lifecourse determinants in the development of T2DM. |
Organizations involved