Research

Chemical Sciences

Title :

Electrosynthesis of functionalized heterocycles via C-H functionalization

Area of research :

Chemical Sciences

Principal Investigator :

Prof. Goutam Brahmachari, Visva Bharati University, West Bengal

Timeline Start Year :

2022

Timeline End Year :

2025

Contact info :

Equipments :

Details

Executive Summary :

A resurgence of interest in organic electrochemistry has led to a boom in new synthetic methodologies and their mechanistic understandings. As part of applying green tools, organic electrosynthesis has become influential in modern synthetic chemistry and find practical applications, both in academia and industry, due to low energy consumption, mildness, and environmental friendliness. Electrosynthesis has led to several unprecedented methodologies. Much of the promise of such a technique hinges on their ability to achieve unique bond constructions that are not possible using established protocols. Synthetic chemists, thus, have been motivated to exploit the use of electrosynthesis in developing efficient strategies for potential organic small molecules. Still, this spectacular field of research is growing in the scenario of global chemical research, and it is high time to undertake dedicated research to explore the area at large. Hence, the present proposal has been designed based on the inherent usefulness and efficacy of electrochemical strategy in developing advanced synthetic methods for promising heterocycles via C-H functionalization. The C-H functionalization technique has emerged as a fascinating strategy in the recent past due to its handful of advantages. Besides, certain unprecedented organic transformations under electrochemical synthesis are anticipated to explore that would enrich the domain of the current knowledge in chemical sciences. In addition, the outcomes of this present proposal would also boost the ongoing practice of green chemistry research. Based on the unique features and the current renaissance in synthetic electrochemistry, it is anticipated that this field will soon be considered as a reliable and versatile platform by the broader scientific community for nontraditional bond construction in organic chemistry. It is thus high time to take the challenge to expand and explore the field by organic and medicinal chemists. The present research proposal is a dedicated endeavour to this scientific cause! Given this background and coupled with our ongoing endeavours in developing green chemistry-directed practical and effective protocols for bio-relevant molecules, the present investigator is highly motivated to design and develop electrosynthetic strategies for diverse series of heterocycles via C-H functionalization, particularly focusing on the biologically promising coumaroyl, indazole and phenazine scaffolds.

Total Budget (INR):

46,49,832

Organizations involved