Life Sciences & Biotechnology

Title :

Unravelling the molecular mechanisms of Spinocerebellar Ataxia 8 non-coding RNA pathogenesis associated neurodegeneration using Drosophila model

Area of research :

Life Sciences & Biotechnology

Focus area :

Molecula Biology, Genetics

Principal Investigator :

Dr. Mousumi Mutsuddi, Associate Professor, Banaras Hindu University

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

The study uses a Drosophila model of Spinocerebellar Ataxia 8 to understand the molecular genetics of the disorder. RNA binding proteins (RBPs) like muscleblind, split ends, staufen, and spoonbill are identified as potential modulators. Spoonbill RBP, with a KH RNA binding domain, suppresses SCA8-associated neurodegeneration and motor problems. The researchers plan to explore the mechanisms of SCA8 pathogenesis and their implications for other disorders like myotonic dystrophy using Drosophila models.


Prof. Ashim Mukherjee, Banaras Hindu University

Total Budget (INR):


Organizations involved