Life Sciences & Biotechnology
Title : | Unravelling the molecular mechanisms of Spinocerebellar Ataxia 8 non-coding RNA pathogenesis associated neurodegeneration using Drosophila model |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Molecula Biology, Genetics |
Principal Investigator : | Dr. Mousumi Mutsuddi,
Associate Professor,
Banaras Hindu University |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | mousumi@bhu.ac.in |
Details
Executive Summary : | The study uses a Drosophila model of Spinocerebellar Ataxia 8 to understand the molecular genetics of the disorder. RNA binding proteins (RBPs) like muscleblind, split ends, staufen, and spoonbill are identified as potential modulators. Spoonbill RBP, with a KH RNA binding domain, suppresses SCA8-associated neurodegeneration and motor problems. The researchers plan to explore the mechanisms of SCA8 pathogenesis and their implications for other disorders like myotonic dystrophy using Drosophila models. |
Co-PI: | Prof. Ashim Mukherjee, Banaras Hindu University |
Total Budget (INR): | 0 |
Organizations involved
