Life Sciences & Biotechnology

Title :

Development and functional characterization of glycation resistant insulin for diabetic therapy

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Diabetic therapy

Principal Investigator :

Dr Mahesh J. Kulkarni, Scientist, CSIR-National Chemical Laboratory (CSIR-NCL), Pune

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: To produce glycation resistant proteoforms of insulin by site-directed mutagenesis of lysine and arginine residues. To evaluate the binding and activity of recombinant insulin in vitro by using biophysical and cell-based assays . To evaluate the in vivo efficiency, pharmocokinetics and immune response of recombinant insulin using diabetic rat model. To perform preclinical (toxicological studies) using diabetic rat models.

Organizations involved