Life Sciences & Biotechnology

Title :

Seroepidemiology, matenal immun status and missed diagnosis of pertussis in India- A multicentric study

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Infections of fetus, neonate and pediatric age groups

Principal Investigator :

Dr Rajlakshmi Viswanathan, Scientist, National Institute of Virology (NIV), Pune

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

This project has been developed to study the impact of maternal immune status on infant susceptibility to pertussis through a multicentre seroepidemiological and surveillance study.India alone has contributed 37,274 pertussis cases to the global burden in 2016. Despite this, very little information on pertussis is available from India in recent years. Diagnosis of pertussis largely remains clinical, as laboratory services are usually not available except in a few apex institutions . A recent multinational serosurveillance study, conducted in ten Asian countries, including India demonstrated serologic evidence of significant circulation of B. pertussis amongst Asian children and adolescents regardless of vaccination background. There is therefore an urgent need to further study the seroepidemiology of pertussis in general population and pregnant women and generate evidence for identification of age groups which may potentially benefit from booster immunizations The study will also generate information on pertussis immunity among different age groups, focusing on adolescents and women of child bearing age. Laboratory capacity for pertussis diagnostics will be strengthened through implementation of this project.

Total Budget (INR):


Achievements :

Medical microbiologist with experience of establishing laboratory networks,contributed to understanding antimicrobial resistance in neonatal sepsis, estimation of birth prevalence of congenital CMV infection ,experience of outbreak investigation as a public health microbiologist

Publications :


Innovation (Innovations/ Patents/ Tech Transfer) :

Low cost sample transport system for blood culture.


It will help to understand impact of maternal immunity on susceptibility to pertussis among non immunized and partially immunized young infants Data generated will contribute to decision making towards a vaccination stategy for pregnant women in India.

Organizations involved