Medical Sciences

Title :

Leishmaniasis: target specific approaches to affect host-pathogen interaction and disease process

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Disease pathology

Principal Investigator :

Dr Subrata Adak, Scientist, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: Communication of anti-inflammatory signal from infected macrophage to neighboring cells: Effect on niche creation for Ld infection. Evaluating the potential of host derived Wnt in promoting resistance to Leishmania donovani infection. Cholesterol induced modulation of the leishmanial KMP-11 protein-macrophage interaction. Role of Leishmania derived linoleate in immunoregulation of macrophage. Role of Leishmania y-glutamyl cyclotransferase (ChaC) like protein in pathogenesis of this parasite. Understanding the genome fluidity during the process of gain or loss of virulence in Leishmania.

Organizations involved