Medical Sciences

Title :

Investigating interactions at the host-pathogen interface in the pathogenesis of Mycobacterium tuberculosis

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Pathogenesis of Tuberculosis

Principal Investigator :

Dr Raghunand R Tirumalai, Scientist, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: To access the immunomodulatory properties of unusula PE/PPE gene clusters in M.tb. To identify the host interacting partners and characterise their associated signalling pathways. To perform structure based identification of lignad (PE/PPE)- (host) receptor interfaces suitable for design of small molecules inhibitors. To access the the possible role of cytoskeletal elements in mycobacterial entry. To dissect the functional role of memberane lipids in mycobacterial entry.

Organizations involved