Life Sciences & Biotechnology
Title : | Development of Live and Inactivated Duck Viral Hepatitis Vaccine- An Emerginf Disease of Ducks in India |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Veterinary Science |
Principal Investigator : | Dr. Ramya Rajendran, Tamil Nadu Veterinary And Animal Sciences University, Chennai, Tamil Nadu |
Timeline Start Year : | 2022 |
Timeline End Year : | 2025 |
Contact info : | ramyavet@gmail.com |
Equipments : | Tissue homogenizer
Micropipettes
Egg incubator
DISK ROTATOR
waterbath
Pipette controller
Deep freezer(-20 c) with accessories |
Details
Executive Summary : | Duck rearing plays an important role in the upliftment of socio-economic status of rural poor of India. Duck viral hepatitis (DVH) is a highly fatal, contagious and rapidly spreading viral infection, characterized primarily by hepatitis. DVH can be prevented by vaccination of breeders or ducklings using available live or inactivated vaccines. Recently, positive cases were confirmed from the duck farms located at Thiruvallur district and Salem district of Tamilnadu (Unpublished data). Similarly, a report shows that 2.71% of mortality out of 9.34 % total annual mortality in duck farm in Regional Station, Central Avian Research Institute, Bhubaneswar was due to hepatitis. This clearly states that screening for duck hepatitis virus from susceptible duck population would pave way to study about the prevalence of circulating viruses in the country. This data in turn would help in the development of vaccine to control and prevent the deadly disease caused by duck hepatitis virus in ducks. To the best of our knowledge, there is no vaccine available in India for DVH that is developed using a local isolate. Hence, considering the emergence of the disease and losses to the duck farmers, it is realized that there is a national need to develop a vaccine for DVH using the indigenous isolates to protect the duck population against the disease. Hence, the present project has proposed with the following objectives; Isolation of circulating duck hepatitis virus in embryonated duck eggs/ chicken eggs/ primary duck embryo liver/ kidney cells / suitable cell lines, followed by attenuation of the isolate. Production of live and inactivated vaccines using the indigenous isolates. Studying the immunogenicity of the developed live and inactivated vaccines. The outcome of the proposal would be development of live and inactivated indigenous vaccine for duck viral hepatitis and establishing data about the circulating duck hepatitis virus in India. This in turn will pave way for the improvement of socioeconomic status of duck farmers of the country by preventing the mortality in ducks due to duck viral hepatitis. |
Co-PI: | Dr. Madhanmohan Muthukrishnan, Tamil Nadu Veterinary And Animal Sciences University, Chennai, Tamil Nadu-600051, Dr. S Jaisree, Tamil Nadu Veterinary And Animal Sciences University, Chennai, Tamil Nadu-600051, Dr. Manoharan Seeralan, Tamil Nadu Veterinary And Animal Sciences University, Chennai, Tamil Nadu-600051 |
Total Budget (INR): | 29,93,445 |
Organizations involved