Life Sciences & Biotechnology
Title : | Development of deployable nanozyme-based point-of-care testing devices for multiplex detection of cardiovascular biomarkers |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. Indrani Nandi, Indian Institute Of Technology (IITBHU), Uttar Pradesh |
Timeline Start Year : | 2022 |
Timeline End Year : | 2024 |
Contact info : | nandiindrani93@gmail.com |
Details
Executive Summary : | Cardiovascular diseases (CVD) are the most significant non-communicable diseases worldwide, causing nearly 17.7 million deaths annually. One-fifth of these deaths occur in India, particularly among the younger population. The global burden has significant economic consequences, with an estimated $2.4 trillion loss between 2012-2030. Indians face concerns due to early-onset age, fast disease progression, and high mortality rates. With over 54% of the population below 25 years old, India is at a higher risk of epidemic proportions unless immediate interventions are taken. COVID-19 has been observed to worsen underlying CVD and cause new cardiac complications. Smart diagnostic systems are needed to monitor disease early stages at lower costs and without laboratory dependence, enabling timely clinical attention. Point-of-care testing (POCT) devices are increasingly popular for this purpose, but biosensors using natural enzymes face issues such as decreasing catalytic activity, enzyme saturation, and high purification costs. To overcome these challenges, nanozymes (nanomaterial-based artificial enzymes) are proposed as a solution. These nanomaterials can overcome the drawbacks of natural enzymes and provide signal amplification with a lower detection limit. India, being resource-limited in healthcare, holds a huge market for low-cost diagnostic sensors. Biocompatible enzyme-mimicking nanomaterials will be developed, and their catalytic properties explored through surface modifications for the detection of CVD biomarkers like cholesterol, LDL, HDL, and cardiac troponin. This study aims to track individual health status and enable early-stage diagnosis of CVD in a personalized manner. |
Organizations involved