Computer Sciences and Information Technology

Title :

Designing of hybrid molecules for various targets of inflammatory disorders using computer aided molecular modeling

Area of research :

Life Sciences & Biotechnology, Computer Sciences and Information Technology

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Principal Investigator :

Dr. Srinivasan Ramachandran, Scientist, Institute of Genomics and Integrative Biology (IGIB), New Delhi

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Executive Summary :

New compound alpha keto pimelic acid (KPA) has been assayed for inhibition of dapA. This compound displays time-dependent inhibition and kinetic studies show this inhibitor act as a competitive inhibitor against substrate pyruvate that has not previously been observed for inhibition of dapA. Therefore, this scaffold could have the potential to inhibit Mtb dapA would represent promising starting point as lead compound and certainly aid the experimental designing of antitubercular in lesser time.

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Organizations involved