Life Sciences & Biotechnology
Title : | Information theoretic analysis of quorum sensing network in Vibrios. |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Mr. Mintu Nandi, Indian Institute Of Engineering Science And Technology, West Bengal |
Timeline Start Year : | 2022 |
Timeline End Year : | 2024 |
Contact info : | nandiimintu@gmail.com |
Details
Executive Summary : | The quorum sensing network in Vibrio Harveyi is a widely studied signal transduction network that involves the generation, secretion, and detection of autoinducers by individual cells. The concentration of autoinducer depends on local cell density, and when it exceeds a threshold value, significant expression of quorum sensing regulated genes occurs. These genes are responsible for various phenotypes, such as bioluminescence, biofilm formation, and secretion of virulence factors. Information-theoretic analysis can be used to understand the manifestation of signal transduction along the quorum sensing pathway. Autoinducers interact with cognate receptors, forming input channels that collectively regulate its downstream output master regulator (LuxR) through a single channel. The first approach is to characterize the mechanism of signal integration at the autoinducer level and how the signal is processed to downstream factors. During signal propagation, the behavior of each regulatory component in information processing can be quantified, determining the role of each regulatory edge in downstream gene regulation. The study also focuses on understanding cell-to-cell communication using information-theoretic tools. Autoinducers can communicate with cognate sensors of another cell, leading to cell-to-cell communication. The impact of cell division on this communication can be quantified using information theoretic measures. The proposed findings will be achieved through theoretical calculations supported by numerical simulation. |
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