Life Sciences & Biotechnology
Title : | G6PD deficiency and its association with arterial hypertension among the Angami Naga of North-East India |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. Sudipta Ghosh, North Eastern Hill University, meghalaya |
Timeline Start Year : | 2022 |
Timeline End Year : | 2025 |
Contact info : | ghosh.sudiptaa@gmail.com |
Equipments : | "Sphygmomanometer
Harpenden Skinfold Caliper
Hemo-Control (Portable Hb Analyser) Plus Microcuvettes for 600 subjects
Anthropometric Instruments (Anthropometer Rod, Sliding Caliper, measuring tape)
Doppler Ultrasound Echocardiogram machine" |
Details
Executive Summary : | Hypertension is a growing public health concern in both developed and developing countries, particularly in the Asia-Pacific region, including North-East India. The prevalence of hypertension is higher in some ethnic groups than in others, possibly due to an inborn error of metabolism caused by a defect in an enzyme-mediated process and environmental factors. Oxidative stress and impaired synthesis or release of nitric oxide (NO) by pulmonary smooth cells are also important causative factors in hypertension and atherosclerosis. Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been overlooked as a cause of pulmonary hypertension due to an inborn error of metabolism by a sex-linked recessive gene. This deficiency is one of the most common inherited hemolytic disorders, affecting around 500 million people worldwide. G6PD deficient individuals with persistent ingestion of refined carbohydrates are at greater risk of developing hypertension or diabetes mellitus than those without the defect. The Angami Naga tribe in North-East India has the highest prevalence of G6PD deficiency (27.06%) in South-East Asia, but no follow-up study has been conducted to understand the current situation. The Naga tribes from this region are known for prevalence of obesity and hypertension, such as Tankhul Naga and Ao Naga. A preliminary study among the Angami Naga tribe revealed alarmingly high prevalence of both systolic and diastolic hypertension in both males and females. The proposed study aims to investigate the role of G6PD deficiency on hypertension prevalence in the Angami Naga of North-East India. |
Total Budget (INR): | 52,15,520 |
Organizations involved