Life Sciences & Biotechnology

Title :

Development of a tumor-microenvironment responsive, cancer theranostic nanodots for photodynamic-immunotherapy

Area of research :

Life Sciences & Biotechnology

Focus area :

pharmaceuticals, Immunology

Principal Investigator :

Dr. Aniruddha Roy, Associate Professor,Birla Institute of Technology and Science, Pilani

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

The current anticancer therapies primarily target cancer cells, but they are often ineffective in most cases. Cancer is a multi-cellular disorder, and combining two or more treatment modalities can be highly beneficial. A new approach, cyclometalated iridium(III)-based Aggregation Induced Emission (AIE)-active near infra-red (NIR) emissive PS (AIEgen), is proposed for better PDT therapy. This would enable deep penetration of light for photo-activation and overcome drawbacks like aggregation-caused quenching (ACQ). The next generation AIE-based PS could pave the way for simultaneous therapy and diagnosis applications. Combining photodynamic-immunotherapy with AIEgens and a TLR7+8 agonist R848 could significantly improve current treatment strategies.


Prof. Inamur R. Laskar, Birla Institute of Technology and Science, Pilani

Total Budget (INR):


Organizations involved