Life Sciences & Biotechnology

Title :

Novel paradigms for the development of antioxidant-based radio-protective agent by targeting Nrf2 for ameliorating radiation-induced damages

Area of research :

Life Sciences & Biotechnology

Focus area :

Molecular Biology

Principal Investigator :

Dr. Tamizhselvan Gnanasekaran, Assistant Professor, K. S. Hegde Medical Academy, Mangalore

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

The study found that ferulic acid (FA) can reduce radiation-induced DNA damage in peripheral blood. FA was treated with Keap1-Nrf2 protein-protein interaction, a cellular drug target, and showed a significant reduction in reactive oxygen species and DNA damage. The study suggests that FA could be a potential radio-protective agent, with in silico approaches for screening as a better antioxidant-based radio-protector. Quantitative data is needed to understand biological processes in vitro/in vivo.


Dr. Gollapalli Pavan, NITTE University, Karnataka Dr. Suchetha Kumari N, NITTE University, Karnataka

Total Budget (INR):


Organizations involved