Life Sciences & Biotechnology

Title :

Enriching Unnatural Amino Acids (UAAs) toolkit via transition-metal catalyzed site selective functionalization/annulation of distal C(sp2)-H bonds

Area of research :

Life Sciences & Biotechnology

Focus area :

Protein engineering

Principal Investigator :

Dr Rajeev Sakhuja, Associate Professor, Birla Institute of Technology and Science (BITS), Pilani

Timeline Start Year :


Contact info :

Associated Programme / Scheme :

Core Research Grant (CRG)


Executive Summary :

Proteins play a central role in almost every biological process, performing diversified functions in living organisms. The introduction of natural and Unnatural Amino Acids (UAAs) into proteins offers unprecedented capability for site-specific protein manipulation in living systems, and understanding their structure-function relationship. This study proposes to develop transition-metal catalyzed strategies for the distal C(sp2)–H bond functionalization on aryl/heteroaryl motifs of aromatic α-amino acids by envisaging the possibilities of distal C(sp2)–H bond activation, using appropriately stapled directing groups. In addition, annulation on the aromatic moiety in tyrosine and tryptophan would be explored.

Total Budget (INR):


Organizations involved