Life Sciences & Biotechnology

Title :

Deciphering MTP18 as an inner membrane mitophagy receptor in clearance of damaged mitochondrial subdomains and its relevance in mitoptosis

Area of research :

Life Sciences & Biotechnology

Focus area :


Principal Investigator :

Dr Sujit Kumar Bhutia, Associate Professor, National Institute of Technology Rourkela (NITRKL), Rourkela

Timeline Start Year :


Contact info :

Associated Programme / Scheme :

Core Research Grant (CRG)


Executive Summary :

Mitochondrial dynamic is a coordinated cycle of mitochondrial fusion and fission to conserve their distribution, shape, and size. Mitochondrial fission is pre-required for mitophagy to selectively degrade the damaged mitochondria. Human MTP18 is a novel 18kDa nuclear-encoded mitochondrial inner membrane protein, and MTP18 promotes change in mitochondrial morphology from filamentous to spherical fragmented structures. This project aims to investigate the role of MTP18 to induce selective mitophagy through asymmetric fission to eliminate the damaged mitochondrial subdomains.

Total Budget (INR):


Organizations involved