Life Sciences & Biotechnology, Medical Sciences, Pharmaceutical Sciences


A Novel Molecule Effective for Non-steroidal Anti-inflammatory Drug Induced Gastropathy


Life Sciences & Biotechnology, Medical Sciences, Pharmaceutical Sciences

Focus Area:

Prevention of Gastric Mucosal Injury


EP2616439, JP5868980, US8901317

Social Benefits:

Discovered indigenously. Safe and stable. Immense therapeutic potential; These derivatives can chelate free iron, prevent oxidative stress by scavenging ROS and simultaneously offer anti-apoptotic effect in vitro. These derivatives have the ability to prevent the formation of iron-mediated. OH as well as scavenge ROS in vivo. We have shown that these derivatives can prevent gastric mucosal oxidative stress and gastropathy by preventing ROS-mediated activation of apoptosis in gastric mucosal cells induced by NSAIDs. This invention provides a new small molecule having gastroprotective efficacy and a new strategy for drug discovery in gastropathy

Developing Agency:

CSIR-Indian Institute of Chemical Biology (IICB), West Bengal

Technology Readiness Index:

Lab Validation

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Brief Description

Description :

A novel small molecule which can prevent gastro trouble arising from use of pain killers. Tryptamine derivatives are useful as antioxidant and anti-apoptotic effect to prevent gastropathy/gastric mucosal injury induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), stress and ethanol.

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