Research
Title : | Studies on macrophage-T cells interaction in mouse model of malaria: Role of Th17 cells |
Area of research : | Medical Sciences |
Focus area : | Malaria |
Principal Investigator : | Dr. Jyoti Das, Scientist, National Institute of malaria Research (NIMR), New Delhi, |
Timeline Start Year : | 2011 |
Timeline End Year : | 2015 |
Contact info : | jyoti@mrcindia.org |
Details
Executive Summary : | The blood stage malaria infection by Plasmodium berghei activates various immune cells. Somehow these activated cells differentiate into Treg, and the factors that drive t cell expansion or differentiation is unknown. We found high levels of CD4+ICOS+Foxp3+ cells, which are highly immunosuppressive in nature. We also observed that there is predominant secretion of IL-10 as the parasitic load increases which suppresses the immune activation and allows the parasite to grow in the host leading to its demise. |
Co-PI: | Dr. T Adak, Scientist, National Institute of malaria Research (NIMR), New Delhi |
Total Budget (INR): | 29,10,000 |
Organizations involved
Implementing Agency : | National Institute of malaria Research (NIMR), New Delhi 110077 Funding Agency :Indian Council of Medical Research (ICMR), New Delhi | |