Research
Title : | Investigating The Role Of Bmp Signaling In Pathogenesis Of Osteoarthritis |
Area of research : | Medical Sciences |
Focus area : | Tissue engineering |
Principal Investigator : | Dr. Amitabha Bandyopadhyay, Indian Institute of Technology (IIT), Kanpur, India |
Timeline Start Year : | 2017 |
Timeline End Year : | 2020 |
Contact info : | abandopa@iitk.ac.in |
Details
Executive Summary : | Osteoarthritis is by far the most common disease afflicting the musculo-skeletal system. At present this disease is only treated symptomatically and in extreme cases by prosthetic replacement. No disease modifying therapy is available. In this proposal I plan to investigate if ectopic exposure of articular cartilage to BMP signaling can induce osteoarthritis in mouse. Based on several lines of argument we hypothesize that adult stage trans-differentiation of articular/permanent cartilage, induced by BMP signaling, causes osteoarthritis. If this hypothesis turns out to be true it can immediately suggest possible disease modifying therapy for osteoarthritis. |
Co-PI: | None |
Total Budget (INR): | 70,61,894 |
Achievements : | Work in progress – possible pharmacological disease modifying therapy for osteoarthritis. |
Patents : | NO |
Innovation (Innovations/ Patents/ Tech Transfer) : | N/A |
Outcome/Output: | Work in progress |
Organizations involved
Implementing Agency : | Indian Institute of Technology (IIT), Kanpur, India Funding Agency :Department of Biotechnology (DBT), Govt. of India | |